Bicyclic derivatives of 1,4-dihydropyridine 3,5-carboxylic acid

Details Bicyclic derivatives of 1,4-dihydropyridine 3,5-carboxylic acid Bicyclic derivatives of 1,4-dihydropyridine 3,5-carboxylic acid

1974-12-13

1976-10-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31505

Patent

active

039884589

ABSTRACT:
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

REFERENCES:
patent: 3511837 (1970-05-01), Bossert et al.
patent: 3773773 (1973-11-01), Bossert
patent: 3775422 (1973-11-01), Bossert
patent: 3799936 (1974-03-01), Meyer et al.

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