Bicyclic derivatives as PPAR modulators

Details Bicyclic derivatives as PPAR modulators Bicyclic derivatives as PPAR modulators

2004-12-16

2009-06-09

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S406000, C548S361100

Reexamination Certificate

active

07544707

ABSTRACT:
The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C0-C8alkyl and C1-4-heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O)2and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.

REFERENCES:
patent: 6982274 (2006-01-01), Oinuma et al.
patent: WO 97/28137 (1997-08-01), None
patent: WO 02/10137 (2002-02-01), None
patent: WO 02/083648 (2002-10-01), None
patent: WO 03/084916 (2003-10-01), None
patent: WO 2004/063155 (2004-07-01), None
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.

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