Bicyclic compounds and their use as excitatory amino acid recept

Details Bicyclic compounds and their use as excitatory amino acid recept Bicyclic compounds and their use as excitatory amino acid recept

1995-06-01

1997-06-24

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 81, 514412, 548251, 548252, 548414, 548452, C07D20902, C07D40312, A61K 3140, A61K 3141

Patent

active

056417985

ABSTRACT:
This invention provides novel bicyclic compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides intermediates useful in the synthesis of excitatory amino acid antagonists.

REFERENCES:
patent: 4691022 (1987-09-01), Henning et al.
patent: 4999370 (1991-03-01), Ruger et al.
Zimmerman, D.M. et al, Trends in Medicinal Chemistry '90, Oxford (1991), pp. 145-151.
Watkins, J.C., Can. J. Physiol. Pharmacol., (1991), vol. 69, pp. 1064-1075.
Rogawski, M.A., Drugs, (1992) vol. 44, No. 3, pp. 279-292.
Ornstein, P.L. et al., J. Med. Chem., (1991), vol. 34, pp. 90-97.

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