Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1987-06-15
1988-08-09
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540460, 540500, 540461, 540523, 544238, C07D24500, C07D48706, C07D23602, A61K 3150
Patent
active
047629240
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, alkanoyl or aroyl; R.sup.2 is hydrogen or alkyl; R.sup.3 is hydrogen or aryl; R.sup.4 and R.sup.5 each are hydrogen or R.sup.4 and R.sup.5 taken together are oxo; and Y is --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --N(R.sup.6)-- in which R.sup.6 is hydrogen, alkyl or aralkyl,
as well as pharmaceutically acceptable salts thereof with bases when R.sup.2 is hydrogen and pharmaceutically acceptable salts thereof with acids when Y is --N(R.sup.6)--, which have antihypertensive activity and can be used as medicaments in the form of pharmaceutical preparations, are described.
The compounds of formula I contain at least one asymmetric carbon atom. Therefore, the invention comprises not only the optically uniform forms of these compounds, but also the various diastereoisomeric racemates and mixtures of different diastereoisomeric racemates.
REFERENCES:
patent: 4307094 (1981-12-01), Hassall et al.
patent: 4341781 (1982-07-01), Hassall et al.
patent: 4512924 (1985-04-01), Attwood et al.
Chemical Abstracts, vol. 106, Item 196463c (1987), Abstracting Japan Kokai Tokkyo Koho JP 62 05 484 [87 05 984], Jan. 12, 1987.
Chemical Abstracts, vol. 106, Item 102247k (1987), Abstracting Attwood et al. in J. Chem. Soc., Perkin Transactions I, (1986), No. (6), pp. 1011-1019.
Notoff et al., Chem. Abst., 103-81466b.
Hassall Cedric H.
Lawton Geoffrey
Redshaw Sally
Bond Robert T.
Hoffmann-La Roche Inc.
Isgro William C.
Leon Bernard S.
Saxe Jon S.
LandOfFree
Bicyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bicyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-919461