Bicyclic carbamoylpyridone derivative having HIV integrase...

Details Bicyclic carbamoylpyridone derivative having HIV integrase... Bicyclic carbamoylpyridone derivative having HIV integrase...

2006-02-20

2010-12-28

Chandrakumar, Nizal S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S117000

Reexamination Certificate

active

07858788

ABSTRACT:
Is to provide a novel compound having an anti-viral activity, particularly a HIV integrase inhibitory activity, and an agent, particularly an anti-HIV agent.A compound represented by the formula:(whereinZ1is NR4(R4is hydrogen, optionally substituted lower alkyl etc.), O or CH2;Z2is optionally substituted lower alkylene or optionally substituted lower alkenylene, each may be intervened by a heteroatom group selected from group consisting O, S, SO, SO2, NR5(R5is selected independently from the same substituent group of R4) —N═ and ═N—;R1is hydrogen or lower alkyl;X is a single bond, a heteroatom group selected from O, S, SO, SO2and NH, or lower alkylene or lower alkenylene each may be intervened by the heteroatom group;R2is optionally substituted aryl;R3is hydrogen, halogen, hydroxy, optionally substituted alkyl group etc.)

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