Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reissue Patent
2005-10-26
2009-06-23
Chang, Celia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S258100, C514S320000, C514S321000, C544S235000, C544S237000, C544S278000, C546S196000, C546S197000, C546S205000, C546S207000, C546S214000
Reissue Patent
active
RE040793
ABSTRACT:
The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1and R2taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl; R3is hydrogen or halo; R4is hydrogen or C1-6alkyl; R5is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk—X—R7, —Alk—Y—C(═O)—R9, or —Alk—Y—C (═O)—NR11R12wherein each Alk is C1-12alkanediyl; and R6is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ring-system; R7is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, SO2or NR8; said R8being hydrogen or C1-6alkyl; R9is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10or a direct bond; said R10being hydrogen, or C1-6alkyl; R11and R12each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R11and R12combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
REFERENCES:
patent: 4711703 (1978-09-01), Lawton
patent: 4722630 (1988-02-01), Fang
patent: 4853394 (1989-08-01), King et al.
patent: 4910193 (1990-03-01), Buchheit
patent: 5130312 (1992-07-01), Van Daele et al.
patent: 5185335 (1993-02-01), Van Daele et al.
patent: 5262418 (1993-11-01), Van Daele et al.
patent: 5374637 (1994-12-01), Van Daele et al.
patent: 5452013 (2002-09-01), Bosmans et al.
patent: 6452013 (2002-09-01), Bosmans et al.
patent: 045862 (1991-09-01), None
patent: 0 445 882 (1991-09-01), None
patent: 0 299 568 (1994-09-01), None
patent: 0 309 043 (1994-11-01), None
patent: 0 389 037 (1995-09-01), None
patent: 0389037 (1995-09-01), None
patent: 0 389 037 (1996-09-01), None
patent: WO 96/33186 (1996-10-01), None
patent: 0 774 460 (1997-05-01), None
patent: WO 97/29739 (1997-08-01), None
patent: 196054 (0000-01-01), None
patent: WO 93/03725 (1993-03-01), None
patent: WO 93/05038 (1993-03-01), None
patent: WO 93/16072 (1993-08-01), None
patent: WO 94/08995 (1994-04-01), None
patent: WO 94/10174 (1994-05-01), None
patent: WO 96/33186 (1996-10-01), None
patent: 96/331186 (1996-10-01), None
patent: WO 97/11054 (1997-03-01), None
Gaster, L. et al., (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate Hydrochloride: A Highly Potent and Selective 5-HT4Receptor Antagonist Derived from Metoclopramide, Journal of Medicinal Chemistry, 1993, vol. 36, No. 25, pp. 4121-4123.
Fancelli, D., et al., Serotoninergic 5-HT3and 5HT4Receptor Activities of Dihydrobenzofuran Carboxylic Acid Derivatives, Bioorganic & Medicinal Chemistry Letters, 1996, vol. 6, No. 3, pp. 263-266.
Lewis, N., et al., Diecetoxpiperidinium Analogs of Acetylcholine, Journal of Medicinal Chemistry, 1973, vol. 16, No. 2, pp. 156-159.
Appl. No. 10/643506, filed Aug. 19, 2005, Janssen Pharmaceutica NV.
Appl. No. 10/560,479, filed Dec. 12, 2005, Janssen Pharmaceutica NV.
Bosmans Jean-Paul Renë Marie Andrë
DeCleyn Michel Anna Jozef
Surkyn Michel
Chang Celia
Janssen Pharmaceutica N.V.
Woodcock & Washburn LLP
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