Bicyclic anilide spirolactam CGRP receptor antagonists

Details Bicyclic anilide spirolactam CGRP receptor antagonists Bicyclic anilide spirolactam CGRP receptor antagonists

2011-08-23

2011-08-23

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S301100, C548S304700, C548S408000, C514S279000, C514S411000

Reexamination Certificate

active

08003792

ABSTRACT:
The present invention is directed to compounds of Formula I:(where variables A1, A2, B, J, K, m, n, R4, R5a, R5band R5care as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

REFERENCES:
patent: 7390798 (2008-06-01), Williams et al.
patent: 7625901 (2009-12-01), Wood et al.
patent: 7629338 (2009-12-01), Wood et al.
patent: 7659300 (2010-02-01), Bell et al.
patent: 7696192 (2010-04-01), Bell et al.
patent: 0183478 (2001-11-01), None
patent: WO2004082605 (2004-09-01), None
patent: WO2004082678 (2004-09-01), None
patent: WO2004083187 (2004-09-01), None
patent: WO2004087649 (2004-10-01), None
patent: WO 2006029153 (2006-03-01), None
patent: WO 2006031491 (2006-03-01), None
Dorwald, 2005, pp. 8 and 9 and preface.
Regis Millet et al , 2002, Antitrypanosomal Activities and Cytotoxicity of 5-Nitro-2-furancarbohydrazides.
Flexyx drugs Spirolactone 2008.
Doggrell, et al., Migraine and beyond: cardiovascular therapeutic potential for CGRP modulators, Expert Opinion Investig. Drugs (2001) 10(6): 1131-1138.
Supplementary European Search Report for EPO Appln. No. 05795448, dated Aug. 3, 2009.

Affiliated with

Also associated with

Rating

Bicyclic anilide spirolactam CGRP receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bicyclic anilide spirolactam CGRP receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic anilide spirolactam CGRP receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2708850