Bicyclic anilide spirohydantoin CGRP receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S273000, C514S275000, C514S278000, C514S367000, C514S370000, C514S375000, C514S389000, C514S392000, C544S230000, C546S015000, C546S017000, C548S147000, C548S216000, C548S301100

Reexamination Certificate

active

10549338

ABSTRACT:
The present invention is directed to compounds of the formula:that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

REFERENCES:
patent: 6548505 (2003-04-01), Martin et al.
Pinder et al. J. Med. Chem. 1971, 14(9), 893-893. * indicates the CAS Abstract and Structures are attached.

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