Bicyclic amino acids as intermediates in the preparation of tric

Details Bicyclic amino acids as intermediates in the preparation of tric Bicyclic amino acids as intermediates in the preparation of tric

1985-09-06

1986-09-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548434, C07D20956

Patent

active

046148051

ABSTRACT:
The invention relates to new derivatives of tricyclic aminoacids, of the formula I ##STR1## in which n denotes 0 or 1, A denotes --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, R denotes hydrogen, alkyl or aralkyl, R.sup.1 denotes hydrogen, or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, or alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, or aralkyl or aroylalkyl, both of which can be substituted as defined above, or a monocyclic or bicyclic S--, O-- and/or N-heterocyclene radical, or a side chain of a naturally occurring aminoacid, which may be protected, R.sup.2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and physiologically acceptable salts thereof, processes for their preparation, agents containing these compounds and their use, and new bicyclic aminoacids as intermediates and processes for their preparation.

REFERENCES:
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patent: 4431644 (1984-02-01), Smith et al.
patent: 4431645 (1984-02-01), Smith et al.
patent: 4558065 (1985-12-01), Urbach et al.
Neustadt et al., Chem Abst. 97-216730p.
Smith et al., Chem. Abst. 100-175294j.
Geiger et al., Chem. Abst. 97-92759h.
Remond et al., Chem. Abst. 97-216716p.

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