Bicyclic amidine derivatives as inhibitors of nitric oxide synth

Details Bicyclic amidine derivatives as inhibitors of nitric oxide synth Bicyclic amidine derivatives as inhibitors of nitric oxide synth

1999-07-22

2000-09-12

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514471, 514213, 514310, A61K 3138, A61K 3134, A61K 3155, A61K 3147

Patent

active

061178985

ABSTRACT:
There are provided compounds of formula (I), ##STR1## wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro or cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents N(X) or CH(--(CH.sub.2).sub.m --NXY); U represents NH, O or CH.sub.2 ; V represents (CH.sub.2).sub.a ; W represents (CH.sub.2).sub.b ; a, b, m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy.

REFERENCES:
patent: 3632593 (1972-01-01), Gutier et al.
patent: 3669974 (1972-06-01), Elpern et al.
patent: 3993469 (1976-11-01), Regal et al.
patent: 4073639 (1978-02-01), Regel et al.
Moncada et al, "Nitric oxide; Physiology, . . . " Pharmacological Reviews, vol. 43, pp. 109-142 (1991).
Nissan Chem. Ind. KK (1989) "Fluorine-contg cpds." (0-38310/42).
Forstermann et al, "Induced RAW 264.7 macrophages express," European J. of Pharmacology-Molec. Pharmac. Sect. vol. 225, pp. 161-165 (1992).
Bredt et al, "Isolation of nitric oxide synthetase . . . ," Proc. Natl. Acad. Sci. (USA), vol. 87, pp. 682-685 (1990).
Pollock et al, "Purification and characterization of . . . ," Proc. Natl. Acad. Sci. (USA), vol. 88, pp. 10480-10484 (1991).

Affiliated with

Also associated with

Rating

Bicyclic amidine derivatives as inhibitors of nitric oxide synth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bicyclic amidine derivatives as inhibitors of nitric oxide synth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic amidine derivatives as inhibitors of nitric oxide synth will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-96677