Bicyclic 6-alkylidene-penems as β-lactamase inhibitors

Details Bicyclic 6-alkylidene-penems as β-lactamase inhibitors Bicyclic 6-alkylidene-penems as β-lactamase inhibitors

2008-08-21

2010-10-12

Berch, Mark L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S347000

Reexamination Certificate

active

07812014

ABSTRACT:
The present invention provides a compound of formula Iwherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; R5is H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHR3OCOC1-C6 alkyl; and R3is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

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