Bicycle compounds, their production and use

Details Bicycle compounds, their production and use Bicycle compounds, their production and use

1981-10-19

1989-04-18

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514563, 560 39, 560 41, 562448, 562449, 562450, A61K 3743, C07C10130, C07C10102, C07C10172

Patent

active

048228184

ABSTRACT:
New bicyclic compounds, inclusive of salts thereof, of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, hydroxyl or lower alkoxy, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen, lower alkyl, amino-lower-alkyl or acylamino-lower-alkyl, R.sup.5 is hydrogen, lower alkyl or aralkyl which may be substituted, R.sup.6 is hydroxyl, lower alkoxy, amino or lower alkylamino, and m and n each means 1 or 2, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

REFERENCES:
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4243678 (1981-01-01), Krastinat
patent: 4256761 (1981-03-01), Suh et al.

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