Biaryl sulfonamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S438000, C514S604000, C514S605000, C549S075000, C546S334000, C564S091000, C564S092000, C564S099000

Reexamination Certificate

active

08039493

ABSTRACT:
The invention is concerned with novel biaryl sulfonamide derivatives of formula (I)wherein R1to R3and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.

REFERENCES:
patent: WO 00/54759 (2000-09-01), None
patent: WO 03/099769 (2003-12-01), None
patent: WO 03/099775 (2003-12-01), None
Anderson et al,Molecular Pharmacology, 66:6 (2004) 1440-1452 XP009115071.
Panday et al,Bioorganic&Medicinal Chemistry Letters, 16:19 5231-5237 (2006).
Lund et al., Arterioscler. Thomb. Vasc. Biol., 23, pp. 1169-1177 (2003).
Mitro et al., Nature, 445, pp. 219-223 (2007).
Joseph et al., Curr. Opin. Pharmacol, 3, pp. 192-197 (2003).
Cao et al., J. Biol. Chem., 278, pp. 1131-1136 (2003).

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