Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-11-29
2005-11-29
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S263210, C514S263220, C514S263230, C514S263200, C514S263370, C544S276000, C544S277000
Reexamination Certificate
active
06969720
ABSTRACT:
The compounds of the present invention are 2,6,9-trisubstituted purine derivatives which are inhibitors of cyclin/cdk complexes. The compounds of the current invention also are potent inhibitors of human cellular proliferation. As such, the compounds of the present invention constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in treating a disorder mediated by elevated levels of cell proliferation in a mammal compared to a healthy mammal by administering to such mammal an effective amount of the compound. Examples of the compounds of the present invention are represented by the following chemical structures:wherein:X=N;V=NH;O;S; orCH2;A=CH2;(CH2)2;(CH2)3;OCH2CH2; orCHCH3;and Y, R1, R2, R3, R4, and n1are defined herein.
REFERENCES:
patent: 5282824 (1994-02-01), Gianturco
patent: 5866702 (1999-02-01), Mackman et al.
patent: 6316456 (2001-11-01), Meijer et al.
patent: 6413974 (2002-07-01), Dumont et al.
patent: 6479487 (2002-11-01), Dumont et al.
patent: 6627633 (2003-09-01), Trova
patent: 6667311 (2003-12-01), Trova
patent: 2002/0032327 (2002-03-01), Lum et al.
patent: 2002/0035252 (2002-03-01), Lum et al.
patent: 2003/0092909 (2003-05-01), Trova
patent: 2003/0125342 (2003-07-01), Trova
patent: 2003/0229105 (2003-12-01), Kashanchi
patent: 2 741 881 (1997-06-01), None
patent: 2793794 (2000-11-01), None
patent: 11222435 (1999-08-01), None
patent: WO 98/05335 (1998-02-01), None
patent: WO 99/07705 (1999-02-01), None
patent: WO 99/43675 (1999-09-01), None
patent: WO 99/43676 (1999-09-01), None
Brooks et al., “The Cell Cycle and Drug Discovery: The Promise and the Hope,”DDT, 4(10):455-464 (1999).
Coleman et al., “Chemical Inhibitors of Cyclin-Dependent Kinases,” in Plattner, ed.,Annual Reports in Medicinal Chemistry, Academic Press, Inc., pp. 171-179 (1997).
Stedman,Stedman's Medical Dictionary, 26thEd., Williams & Wilkins, Baltimore, Maryland, pp. 1534, 1673 (1995).
Mattsson et al., “Current Concepts in Restenosis Following Balloon Angioplasty,”Trends Cardiovasc. Med., 5(5):200-204 (1995).
Nikol et al., “Regulation of Smooth Muscle Cell Proliferation and its Possible Role in Preventing Restenosis Post-Angioplasty,”Wien Klin Wochenschr, 107(13):379-389 (1995).
American Heart Association “Stenosis and Restenosis of Coronary Arteries,” http://americanheartassociation.com/Heart_and_Stroke_A_Z_Guide/sten.html (2001).
Mani et al., “Cyclin-Dependent Kinase Inhibitors: Novel Anticancer Agents,”Exp. Opin. Invest. Drugs, 9(8):1849-1870 (2000).
Fischer et al., “Inhibitors of Cyclin-Dependent Kinases as Anti-Cancer Therapeutics,”Current Medicinal Chemistry, 7:1213-1245 (2000).
Schow et al., “Synthesis and Activity of 2,6,9-Trisubstituted Purines,”Bioorganic&Medicinal Chemical Letters, 7(21):2697-2702 (1997).
Imbach et al., “2,6,9-Trisubstituted Purines: Optimization Towards Highly Potent and Selective CDK1 Inhibitors,”Bioorganic&Medicinal Chemistry Letters, 9:91-96 (1999).
Legraverend et al., “Synthesis and In Vitro Evaluation of Novel 2,6,9-Trisubstituted Purines Acting as Cyclin-Dependent Kinase Inhibitors,”Bioorganic&Medicinal Chemistry, 7:1281-1293 (1999).
Gray et al., “ATP-Site Directed Inhibitors of Cyclin-Dependent Kinases,”Current Medicinal Chemistry, 6:859-875 (1999).
Pérez-Roger et al., “Inhibition of Cellular Proliferation by Drug Targeting of Cyclin-Dependent Kinases,”Current Pharmaceutical Biotechnology, 1:107-116 (2000).
Green et al.,Protective Groups in Organic Synthesis, 2ndEd., New York, New York:John Wiley & Sons, Inc., pp. 318-319, 331-332 (1991).
AMR Technology , Inc.
Berch Mark L.
Nixon & Peabody LLP
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