Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-03-31
1990-06-12
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514345, 514349, 514350, 514352, 546283, 546284, 546296, 546297, 546293, 546305, C07D21353
Patent
active
049333526
ABSTRACT:
Novel carbamates of 2-ureado-6-hydroxy-pyridines have the structural formula ##STR1## wherein n is 0 to 20; R.sub.1 is hydrogen, alkyl which may be substituted, aryl which may be substituted; R.sub.2 is hydrogen, halogen, carboxylic, SO.sub.3 H, NO.sub.2, alkyl or aryl; R.sub.3 and R.sub.4 have the same meaning as R.sub.2 ; Z is N.dbd.C.dbd.O, N.dbd.C.dbd.S, carboxylic, primary or secondary amine and when n.dbd.O, Z may be ##STR2## wherein Q is hydroxyl, amino, carboxylic, sulfhydryl, isocyanato or isothiocyanato. The carbamates of 2-ureado-6-hydroxypyridines react with compounds of interest to form derivatives which will chelate metal ions such as radionuclides or lanthanides, resulting in the radioisotopic or fluorescent labeling of the compounds.
REFERENCES:
patent: 3961063 (1976-06-01), Parish
Lee Mary C.
Moran William R.
Northington-Davis Zinna
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