Bi-directional oligonucleotides that bind thrombin

Details Bi-directional oligonucleotides that bind thrombin Bi-directional oligonucleotides that bind thrombin

1995-12-11

1997-08-19

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536231, 514 44, C12Q 168, C07H 2104, A01N 4372

Patent

active

056587384

ABSTRACT:
The present invention relates to bi-directional nucleic acid ligand compounds wherein at least two oligonucleotides of opposite sequence polarity are linked to a connecting compound at their same respective terminii; either the 5' terminii or the 3' terminii. These compounds are useful for binding protein or small molecule targets and thus may be used as diagnostic or therapeutic agents.

REFERENCES:
Bock et al., "Selection of single-stranded DNA molecules that bind and inhibit human thrombin", Nature 355: 564-566. Feb. 1992.
Griffin et al., "The discovery and characterization of a novel nucleotide-based thrombin inhibitor", Gene 137: 25-31. 1993.
Shaw et al., "Modified deoxyoligonucleotides stable to exonuclease degradation in serum", Nucleic Acids Res. 19: 747-750. 1991.
Huizenga et al., "A DNA aptamer that binds adenosine and ATP", Biochem. 34: 656-665. 1995.
Latham et al., "The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing 5-(1-pentynyl)-2'-deoxyuridine", Nucleic Acids Res. 22: 2817-2822. 1994.

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