Bi-directional oligonucleotides that bind thrombin

Details Bi-directional oligonucleotides that bind thrombin Bi-directional oligonucleotides that bind thrombin

1996-03-12

1997-09-16

Chambers, Jasemine C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, C07H 2104, C12Q 168, A61K 3500

Patent

active

056682654

ABSTRACT:
The present invention relates to bi-directional nucleic acid ligand compounds wherein at least two oligonucleotides of opposite sequence polarity are linked to a connecting compound at their same respective terminii; either the 5' terminii or the 3 ' terminii. These compounds are useful for binding protein or small molecule targets and thus may be used as diagnostic or therapeutic agents.

REFERENCES:
patent: 5399676 (1995-03-01), Froehler
Bock et al (1992) "Selection of single-stranded DNA molecules that bind and inhibit human thrombin" Nature 355:564-566.
Griffin et al (1993) "The discovery and characterization of a novel nucleotide-based thrombin inhibitor" Gene 137:25-31.
Echer et al. (1993) "Rational screening of oligonucleotide combinational libraries for drug discovery" Nucleic Acids Research 21:1853-1856.
Shaw et al (1991) "Modified oligonucleotides stable to exonuclease degradation in serum." Nucleic Acids Res. 19:747-750.
Huizenga et al (1995) "A DNA aptamer that binds adenosine and ATP" Biochem. 34:656-665.
Giver et al. (1993) "Selection and design of high-affinity RNA ligands for HIV-1 Rev." Gene 137:19-24.
Latham et al (1994) "The application of a modified nucleotide in aptamer selection: etc." Nucleic Acids Res. 22:2817-2822.
Lorsch et al (1994) "In vitro selection of RNA aptamers specific for Cyanocobalamin" Biochemistry 33:973-982.

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