Bi-dentate compounds as kinase inhibitors

Details Bi-dentate compounds as kinase inhibitors Bi-dentate compounds as kinase inhibitors

2011-04-05

2011-04-05

Cordero Garcia, Marcela M (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C530S329000, C530S330000, C530S331000

Reexamination Certificate

active

07919581

ABSTRACT:
The present invention provides compound having the general structure A or pharmaceutically acceptable salts thereof:in-line-formulae description="In-line Formulae" end="lead"?Het-L-P  (A)in-line-formulae description="In-line Formulae" end="tail"?wherein Het is an aromatic moiety comprising a heterocyclic structure mimicking ATP, P is a docking site derived peptide or a docking site peptide mimetic, and L is a linking moiety, wherein L links the ATP mimetic to the docking site peptide moiety. The compounds having the general structure A can serve as inhibitors of kinases, such as the kinases JNK, Erk and p38.

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Barr et al. Identification of the Critical Features of a Small Peptide Inhibitor of JNK Activity. The Journal of Biological Chemistry. 2002, vol. 277, No. 13, pp. 10987-10997.

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