Bi-cyclic pyrimidine inhibitors of TGFβ

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S253000

Reexamination Certificate

active

10811428

ABSTRACT:
Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGFβ activity.

REFERENCES:
patent: 3720674 (1973-03-01), Breuer et al.
patent: 6339072 (2002-01-01), Martin et al.
patent: 248 593 (1987-08-01), None
patent: WO-97/16452 (1997-05-01), None
patent: WO 00/12497 (2000-03-01), None
patent: WO 01/47921 (2001-07-01), None
patent: WO 02/22601 (2002-03-01), None
patent: WO 02/076976 (2002-10-01), None
patent: WO 02/079197 (2002-10-01), None
patent: WO-03/078423 (2003-09-01), None
patent: WO-03/078426 (2003-09-01), None
patent: WO-03/078427 (2003-09-01), None
Roberts and Sporn, Handbook of Experimental Pharmacology (1990) 95: 419-458.
International Search Report for PCT/US04/09300, mailed on Jan. 4, 2005, 2 pages.
Birnbaumer et al., Cell 1992 vol. 71 pp. 1069-1072.
Cooper et al., J Chem Soc Perkin Trans 1984 vol. 1 pp. 799-809.
Crawford et al., Cell 1998 vol. 93 pp. 1159-1170.
Dowd et al., Tetrahedron 1991 vol. 47 pp. 4847-4860.
Greco et al., Tetrahedron Lett 1992 vol. 33(35) pp. 5009-5012.
Lawrence et al Eur J. Cytokine Network 1996 vol. 7 pp. 363-374.
Lin et al., Cell 1992 vol. 68 pp. 775-785.
Lopez-Casillas et al., Cell 1991 vol. 67 pp. 785-795.
Lyons et al., Eur J. Biochem 1990 vol. 187 p. 467.
Massague et al., Cell 1992 vol. 69 pp. 1067-1070.
Massague et al Ann Cell Biol 1990 6 597-646.
Massague et al Ann Rev Biochem 1998 vol. 67 pp. 753-791.
Moyer et al., J Org Chem 1985 vol. 50 pp. 5223-5230.
Munger et al., Cell 1999 pp. 319-328.
Munger et al., Kidney Intl 1997 vol. 51 pp. 1376-1374 and 1376-1382.
Wahl et al., Immunol Today 1989 vol. 10 pp. 258-261.
Wang et al., Cell 1991 vol. 67 pp. 797-805.
Wang et al., Tetrahedron 1998 vol. 29 pp. 8355-8370.
Wolff et al., J Med Chem 1970 vol. 13(3) pp. 531-534.
Wrana et al Cell 1992 vol. 71 pp. 1003-1014.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bi-cyclic pyrimidine inhibitors of TGFβ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bi-cyclic pyrimidine inhibitors of TGFβ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bi-cyclic pyrimidine inhibitors of TGFβ will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3813107

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.