Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-09-05
1999-12-07
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 530325, 530326, 530327, 530328, 435 691, 435 697, 4241851, 4241921, C07K 100, A61K 3800, C12P 2104
Patent
active
059985836
ABSTRACT:
A novel death agonist, BID, which contains only a BH3 domain but not the BH1, BH2, BH4 or membrane anchoring domains found in related BCL-2 family members is provided along with derivatives of BID, bid polynucleotides and derivatives thereof and compositions and uses therefor.
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Tanaka et al, J. Biol Chem. 268(15): 10920-10926, May 25, 1993.
Oltvai and Korsmeyer, Checkpoints of Dueling Dimers Foil Death Wishes, Cell 79:189-192, 1994.
Korsmeyer, Bcl-2 Initiates a New Category of Oncogenes: Regulators of Cell Death, Blood 80:879-886, 1992.
Zha et al., Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2, J. Biol. Chem. 271:7440-7444, 1996.
Boyd et al., Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins, Oncogene 11:1921-1928, 1928.
Chittenden et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions, Embo. J. 14:5589-5596, 1995.
Boise et al., bcl-x, a bcl-2-Related Gene That Functions a a Dominant Regulator of Apoptotic Cell Death, Cell 74:597-608, 1993.
Han et al., The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein, Genes & Dev. 10:461-477, 1996.
Hunter and Parslow, A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis, J. Biol. Chem. 271:8521-8524, 1996.
Hutzell Paula K.
Washington University
Worrall Timothy A.
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