BH3 interacting domain death agonist

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530324, 530325, 530326, 530327, 530328, 435 691, 435 697, 4241851, 4241921, C07K 100, A61K 3800, C12P 2104

Patent

active

059985836

ABSTRACT:
A novel death agonist, BID, which contains only a BH3 domain but not the BH1, BH2, BH4 or membrane anchoring domains found in related BCL-2 family members is provided along with derivatives of BID, bid polynucleotides and derivatives thereof and compositions and uses therefor.

REFERENCES:
Hillier et al, Genbank Accession H23042, Jul. 6, 1995.
Sambrook et al, Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, pp. 16.3-16.4, 16.17-16.29, and 17.37-17.41, 1989.
Tanaka et al, J. Biol Chem. 268(15): 10920-10926, May 25, 1993.
Oltvai and Korsmeyer, Checkpoints of Dueling Dimers Foil Death Wishes, Cell 79:189-192, 1994.
Korsmeyer, Bcl-2 Initiates a New Category of Oncogenes: Regulators of Cell Death, Blood 80:879-886, 1992.
Zha et al., Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2, J. Biol. Chem. 271:7440-7444, 1996.
Boyd et al., Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins, Oncogene 11:1921-1928, 1928.
Chittenden et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions, Embo. J. 14:5589-5596, 1995.
Boise et al., bcl-x, a bcl-2-Related Gene That Functions a a Dominant Regulator of Apoptotic Cell Death, Cell 74:597-608, 1993.
Han et al., The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein, Genes & Dev. 10:461-477, 1996.
Hunter and Parslow, A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis, J. Biol. Chem. 271:8521-8524, 1996.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

BH3 interacting domain death agonist does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with BH3 interacting domain death agonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and BH3 interacting domain death agonist will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-825273

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.