Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-09-09
1999-09-21
Hutzell, Paula K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 234, 435 691, 435 697, 435 711, 514 12, 530350, C07H 2104, C07H 2102
Patent
active
059555939
ABSTRACT:
A novel death agonist, BID, which is related to the BCL-2 family of apoptosis regulating proteins only in the conserved BH3 domain, is provided along with encoding polynucleotides. BID polypeptides and derivatives thereof are useful in modulating apoptosis. Polynucleotides encoding BID polypeptides and derivatives thereof are useful as templates for recombinantly expressing BID polypeptides, as probes for detecting endogenously expressed BID polynucleotides, and in gene therapy for treating or preventing disease. Methods for modulating inappropriate expression of BID using BID antisense molecules or anti-BID antibodies are also provided. In addition, screening assays for identifying agents which modulate binding between BID and other BCL-2 family members are provided.
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Hutzell Paula K.
Washington University
Worrall Timothy A.
LandOfFree
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