.beta.-sulfonyl hydroxamic acids

Details .beta.-sulfonyl hydroxamic acids .beta.-sulfonyl hydroxamic acids

1997-09-19

1998-12-08

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562621, C07D23340

Patent

active

058471537

ABSTRACT:
The present invention provides a compound of formula I ##STR1## or pharmaceutical acceptable salts thereof wherein R.sub.1 is C.sub.4-12 alkyl, C.sub.4-12 alkenyl, C.sub.4-12 alkynyl, --(CH.sub.2).sub.h -C.sub.3-8 cycloalkyl, --(CH.sub.2).sub.h -aryl, or --(CH.sub.2).sub.h -het; R.sub.2 is C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl, --(CH.sub.2).sub.h -C.sub.3-8 cycloalkyl, --(CH.sub.2).sub.h -C.sub.3-8 cycloalkenyl, --(CH.sub.2).sub.h -aryl, --(CH.sub.2).sub.h -het, --(CH.sub.2).sub.h -Q, --(CH.sub.2).sub.i -X-R.sub.4, or --(CH.sub.2).sub.i CHR.sub.5 R.sub.6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.

REFERENCES:
patent: 5240958 (1993-08-01), Campion et al.
patent: 5525629 (1996-06-01), Crimmin et al.
patent: 5691382 (1997-11-01), Crimmin et al.
Database CAPLUS, No. 125:266005, Hodgkin et al., `Use of matrix metalloproteinase inhibitors for treatment of diseases mediated by TGF-alpha.` abstract of WO 9625156 A1, Aug. 22, 1996.
Database CAPLUS, No. 128:75188, Takahashi et al., Preparation and formulation of aryl sulfides, sulfoxides, and sulfones as matrix metalloproteinase inhibitors.' abstract of WO 9749679 A1, Dec. 13, 1997.

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