.beta..sub.3 integrin cytoplasmic domain specific peptide and nu

Details .beta..sub.3 integrin cytoplasmic domain specific peptide and nu .beta..sub.3 integrin cytoplasmic domain specific peptide and nu

1995-06-01

1997-12-23

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530350, 536 231, 536 235, C07K 14705, C07H 2104

Patent

active

057009082

ABSTRACT:
The invention is directed to a peptide having the amino acid sequence of the cytoplasmic domain of integrin subunit .beta..sub.3 ', KFEEERARAKWDTVRDGAGRFLKSLV, or subsequences thereof, and the nucleic acid encoding that peptide.

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Rudinger, Peptide Hormones, Parsons (ad.) U. Park Press. Baltimore, pp. 1-7 (1976).
Marcantonio, E.E. and Hynes, R.O. "Antibodies to the Conserved Cytoplasmic Domain of the Integrin .beta..sub.1 Subunit React with Proteins in Vertebrates, Invertebrates and Fungi." The J. Cell Biol. 106:1765-1772 (1988).
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Dejana E. et al., "Fibronectin and Vitronectin Regulate the Organization of Their Respective Arg-Gly-Asp Adhesion Receptors in Cultured Human Endothelial Cells." J. Cell Biol. 107:1215-1223 (1988).
Burn, P. et al., "Dynamic Membrane-Cytoskeletal Interactions: Specific Association of Integrin and Talin Arises In Vivo After Phorbol Ester Treatment of Peripheral Blood Lymphocytes." Proc. Natl. Acad. Sci. USA 85:497-501 (1988).
Seaver, Sally S. "Monoclonal Antibodies in Industry: More Difficult Than Originally Thought." Genetic Engineering News. pp. 10 and 21 (1994).

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