Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-01-01
2008-01-01
Spector, Lorraine (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007710, C435S007800
Reexamination Certificate
active
10685898
ABSTRACT:
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
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Copeland Robert A.
Hendrick Joseph
Kornacker Michael G.
Lai Zhihong
Lee Ving
Bristol--Myers Squibb Company
Emch Gregory S.
Handler Melissa
Lamerdin John A.
Spector Lorraine
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