Beta secretase exosite binding peptides and methods for...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C435S007710, C435S007800

Reexamination Certificate

active

07314726

ABSTRACT:
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.

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Vassar, et al., “β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE,” Science, vol. 286, pp. 735-741 (1999).
Sidhu, et al., “Phage Display for Selection of Novel Binding Peptides”, Methods in Enzymology, vol. 328, pp. 333-363 (2000).
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