Beta retinoic acid response elements compositions and assays

Details Beta retinoic acid response elements compositions and assays Beta retinoic acid response elements compositions and assays

1989-11-16

1992-02-25

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4351723, 4353201, 536 28, 536 29, 935 6, 935 9, 935 22, 935 33, C07H 1700

Patent

active

050915185

ABSTRACT:
The present invention provide transcriptional control regions, expression vectors comprising said regions, mammalian cells transformed to transcribe and express genes from said vectors, and various methods of assaying compounds for hormone agonist or antagonist activity, all based on discovery of response elements of the .beta.-retinoic acid receptor and of the activation of said response elements in all mammalian cells without need to transform the cells to express the receptor independently of endogenous expression thereof.

REFERENCES:
Chandler et al., Cell, vol. 33, 489-499, Jun. 1983.
Klein-Hitpass Nucleic Acids Research, vol. 16, No. 2 647-663 (1988).
Evans, Science, vol. 240 889-895, May 13, 1988.
Green et al., Trends in Genet., Nov. 1988, vol. 4, No. 11, 309-314.
Umesono et al., CA Abstracts: CA110 (3): 19312q, Nature (London), 336(6196) 262-265 (1988).

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