.beta.-polypeptide foldamers of well-defined secondary structure

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...

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530324, 530350, 530333, 530332, 530331, 530330, C07K 5023

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active

060605855

ABSTRACT:
Disclosed are .beta.-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the .alpha. and .beta. carbons of the peptide backbone. The .beta.-peptides adopt stable helical and sheet structures in both the solid state and in solution. Method of generating combinatorial libraries of peptides containing .beta.-peptide residues and the libraries formed thereby are disclosed.

REFERENCES:
Seebach et al. (1996), Helv. Chim. Acta. 79:913-941.
Seebach et al. (1996), Helv. Chim. Acta. 79:2043-2066.
Dado and Gellman (1994) J. Am. Chem. Soc. 116:1054-1062.
Suhara et al. (1996) Tetrahedron Lett. 37:(10):1575-1578.
Ellman (1996) Acc. Chem. Res. 29:132-143.
Nohira et al. (1970) Bull. Chem. Soc. Jpn. 43:2230.
Lam et al. (1977) Chem. 97:411-448.
Herradon and Seebach (1989) Helv. Chim. Acta. 72:690-714.
Tilley et al. (1992) J. Med. Chem. 35:3774-3783.
Kobayashi et al. (1990) Chem. Pharm. Bull. 38:350.
Blake et al. (1964) Am. Chem. Soc. 86:5293.
Cooper et al. (1993) J. Chem. Soc. Perkin Trans. 1:1313.
Jefford and McNulty (1994) J. Helv. Chim. Acta. 77:2142.
Podlech and Seebach (1995) Liebigs Ann. 1217.
Bodanszky et al. (1984) The Practice of Peptide Synthesis; Springer Verlag, New York.
Appella et al, J. Am. Chem. Soc. 1996, vol. 118, pp. 13071-72.
Karle et al., Journal Am. Chem. Soc., Oct. 1, 1997, vol. 119, No. 39, 9087-9095.

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