Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...
Patent
1998-03-04
2000-05-09
MacMillian, Keith D.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides with at least one nonpeptide bond other than a...
530324, 530350, 530333, 530332, 530331, 530330, C07K 5023
Patent
active
060605855
ABSTRACT:
Disclosed are .beta.-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the .alpha. and .beta. carbons of the peptide backbone. The .beta.-peptides adopt stable helical and sheet structures in both the solid state and in solution. Method of generating combinatorial libraries of peptides containing .beta.-peptide residues and the libraries formed thereby are disclosed.
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Appella Daniel H.
Christianson Laurie A.
Chung Yong Jun
Gellman Samuel H.
Klein Daniel A.
MacMillian Keith D.
Wessendorf T. D.
Wisconsin Alumni Research Foundation
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