.beta.-phenylisoserine-(2R,3S), salts, preparation and use there

Details .beta.-phenylisoserine-(2R,3S), salts, preparation and use there .beta.-phenylisoserine-(2R,3S), salts, preparation and use there

1995-04-10

1997-11-04

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, 562465, 562470, 562444, C07D30514, C07C 5948, C07C22900

Patent

active

056841680

ABSTRACT:
.beta.-phenylisiserine-(2R,3S), salts and preparation thereof through the action of ammonia on .beta.-phenylglycidic-(2R,3R) acid and its use in the preparation of taxane derivatives of general formula: ##STR1## wherein R is hydrogen or --COCH.sub.3 ;and R.sub.1 is phenyl or --O--C(CH.sub.3).sub.3.

REFERENCES:
patent: 5294737 (1994-03-01), Ojima
Journal of Organic Chemistry, vol. 56, No. 5, Mar. 1, 1991, pp. 1681-1683, Ojima, et al., Efficient & Practical Asymmetric Sunthesis of the Taxol C-13 Side Chain, N-Benzoyl-(2R,3S)-3-Phenylisoserine, and Its Analogues Via Chiral Ester Enolate-imine Cyclocondensation.
Kamandi et al, "Arch. Pharmazie", vol. 307, pp. 871-878, 1974.
Harada et al, "Bulletin of Chem. Soc. Japan"; vol. 47 (11), pp. 2911-2912, 1974.
Mangatal et al, "Tetrahedron", vol. 45 (13), pp. 4177-4190, 1989.

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