.beta.-oxo-.beta.-benzenepropanethioamide compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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544324, 544335, 544374, 546293, 546331, 5483255, 548205, 548235, 5482678, 548559, 564 74, 564 78, C07C32738, C07C32748, C07D23396, A61K 31165

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active

053328337

ABSTRACT:
The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.

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Darre et al., Bulletin De La Societe Chimique De France No. 3-4 1975, pp. 829-834.
Barluenga et al., J. Chem. Soc. Perkins Trans. 1 1988 pp. 1739-1744.
Datta et al., Synthesis, No. 7 1988 pp. 556-557.
Okujima et al., Chemical Abstracts, vol. 116, 1992, p. 786 Abstract No. 83371j Abstracting JP 03 232853.
Yates et al., Tetrahedron, vol. 44, No. 11, pp. 3159-3170 (1988).

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