.beta.-Oximinoalkylphosphonic acid esters

Chemistry of carbon compounds – Dipeptides – e.g. – aspartame – anserine – carnosine – etc.

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260927R, 260969, 71 86, C07F 940, A01N 5712

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active

045072515

ABSTRACT:
Novel .beta.-oximinoalkylphosphonic acid ester derivatives of general formula B are prepared from the corresponding .alpha.-halo oxime A: ##STR1## wherein R.sup.1 is a substituent selected from the group consisting of H and C.sub.1 -C.sub.20 alkyl, cycloalkyl and aryl substituents;

REFERENCES:
patent: 3819751 (1974-06-01), Dixon
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"Structure, Reactivity, and Biological Activity of O-(Diethyl Phosphoryl)Oximes and O-(Methylcarbamoyl)Oximes of Substituted Acetophenones and .alpha.-Substituted Benzaldehydes", T. R. Fukuto, et al., J. Agr. Food Chem., 17, 923 (1969).
"Nucleophilic Addition and Subsequent Oxime-Assisted Ester Hydrolysis of Diethyl .beta.-Ketopropylphosphonate", P. Livant, et al., J. Org. Chem. 43, 3011 (1978).
"Reaction of Trimethylphosphite with Acetone Oxime", M. P. Osipova, et al., CA, 93, 220863 (1980).
"Reactions of Silyl Phosphites with .alpha.-Halo Carbonyl Compounds, Elucidation of the Mechanism of the Perkow Reaction and Related Reactions with Confirmed Experiments", M. Sekine, et al., J. Org. Chem., 46, 2097 (1981).

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