Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-06-06
1987-10-27
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549491, 549492, A61K 3134, C07D30752
Patent
active
047030585
ABSTRACT:
This invention relates to novel .beta.-methylenefuranethanamines which are mechanism-based inhibitors of dopamine beta-hydroxylase useful as antihypertensive agents.
REFERENCES:
patent: 4454158 (1984-06-01), Bey
J. B. Van der Schoot et al., Arzneimittel-Forschung, 12(9), 902 (1962).
Kaufman, S.; Friedman, S. Pharm. Rev., 1965, 17, 71.
Pieschi, L.; Oehlke, J.; Schoretter, E.; Oehme, P., Pharmazie, 1983, 38, 355.
Hidaka, H. Nature (London) 1971, 231, 54.
Mangold, J. B.; Klinman, J. P., J. Biol. Chem. 1984, 259, 7772.
Colombo, G.; Rajaskekar, B.; Giedioc, D. P.; Villafrance, J. J., J. Biol. Chem. 1984, 259, 1593.
(a) Rajashekar, B.; Fitzpatrick, P. F.; Colombo, F.; Villafranca, J. J., J. Biol. Chem. 1984, 259, 6925, (b) Fitzpatrick, P. F.; Flory, D. R.; Villafranca, J. J., Biochemistry 1985, 24, 2108.
Colombo, G.; Villafranca, J. J., J. Biol. Chem. 1984, 259, 15017.
May, S. W.; Mueller, P. W.; Padgette, S. R.; Herman, H. H.; Philips, R. S., Biochem. Biophys. Res. Commun. 1983, 110, 161.
Creveling, C. R.; van der Schoot, J. B.; Udenfriend, S., Biochem. Biophys. Res. Commun. 1962, 8, 215.
Hori, T.; Sharpless, K. B., J. Org. Chem. 1979, 44, 4204.
Overman, L. E., J. Am. Chem. Soc. 1976, 98, 2901.
Klemm, L. M.; McGuire, T. M.; Gopinath, K. W., J. Org. Chem. 1976, 41, 2571.
Aunis, D.; Murias-Portugal, M. T.; Mander, P. J., Neurochemistry 1975, 24, 425.
Kitz, R.; Wilson, T. B., J. Biol. Chem. 1962, 237, 3245.
Bargar Thomas M.
Broersma, Jr. Robert
McCarthy James R.
Kolano John J.
McDonald Raymond A.
Merrell Dow Pharmaceuticals Inc.
Raymond Richard L.
LandOfFree
.beta.-methylene furanethanamines and use as anti-hypertensive a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .beta.-methylene furanethanamines and use as anti-hypertensive a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .beta.-methylene furanethanamines and use as anti-hypertensive a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1272489