.beta.methyl azetidinone derivatives and stereoselective process

Details .beta.methyl azetidinone derivatives and stereoselective process .beta.methyl azetidinone derivatives and stereoselective process

1990-06-08

1992-01-14

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508, C07B 5300

Patent

active

050812386

ABSTRACT:
An azetidinone derivative having the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen atom or a protective group and R.sup.3 is an alkyl group or hydrogen atom, a process for preparing the same, and a process for preparing an azetidinone derivative having the general formula (II): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as above. The azetidinone derivative (I) of the present invention can be converted into an important intermediate of 1.beta.-methylcarbapenem antibiotics of a selective reduction of the double bond.

REFERENCES:
patent: 3859319 (1975-01-01), Mrowca
patent: 3904672 (1975-09-01), Khifton
patent: 4055721 (1977-10-01), Kawata
patent: 4082810 (1978-04-01), Brown
Patent Abstracts of Japan, vol. 9, No. 180 (C-293) [1903], 25th Jul 1985 & JP-A-60 51171 (Sankyo K.K.) 22-03-1985.
Houben-Weyl "Methoden der Organischen Chemie", vol. V/2a, 1977, pp. 797-805, Georg Thieme Verlag, Stuttgart; V. Jager et al., "Alkine", p. 804.
Chamberlin, J. Amer. Chem. Soc. 107, 1440 (1985).
Ganem, J. Org. Chem 40, 146 (1975).
Brown et al., J. Amer. Chem. Soc. 94, 7159 (1972).
Ozaki, Chem. Abs. 86, 55173q (1976).
Mori, Chem. Letters 1975, pp. 39-42.
Ganem et al., J. Org. Chem. 40, 2846.
Midland, Chem. Abs. 102, 78464 (1984).
Smimagaki, Chem. Abs. 102, 78464 (1984).
Hutchins, Chem. Abs. 101, 6662(1984).

Affiliated with

Also associated with

Rating

.beta.methyl azetidinone derivatives and stereoselective process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .beta.methyl azetidinone derivatives and stereoselective process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .beta.methyl azetidinone derivatives and stereoselective process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-542592