.beta.-Lactones of 2-hydroxy-cyclopentanecarboxylic acid

Details .beta.-Lactones of 2-hydroxy-cyclopentanecarboxylic acid .beta.-Lactones of 2-hydroxy-cyclopentanecarboxylic acid

1979-05-08

1980-09-09

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

26034321, 542400, 542426, 562504, 560122, 542429, C07D30514, A61K 31365

Patent

active

042218098

ABSTRACT:
Novel lactones of the formula ##STR1## wherein the dotted line indicates the optional presence of a second bond, A is a single bond or --CH.sub.2 --CH.sub.2 --, R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.6 is --OR'.sub.A, R'.sub.A is selected from the group consisting of hydrogen, tetrahydropyranyl, alkyl of 1 to 3 carbon atoms and ##STR2## R".sub.A is selected from the group consisting of alkyl of 1 to 3 carbon atoms optionally substituted with carboxyl and phenyl optionally substituted with a member of the group consisting of carboxyl, free hydroxyl, hydroxyl protected with an acyl of 2 to 4 carbon atoms and hydroxyl protected with an easily hydrolyzable group and R and R.sub.6 together form a keto group, R.sub.7 is --(CH.sub.2)m.sub.A --CH.sub.3, m.sub.A is 3,4,5 or 6 and R.sub.6 and R.sub.7 taken together form .dbd. CH--(CH.sub.2)n.sub. A --CH.sub.3 n.sub.A is 2,3,4 or 5 and the wavy lines indicate that the bonds are in one or the other of the possible configurations and when A is a simple bond, the bond between the cyclopentane ring and the oxygen is in the .alpha.-position having hypotensive activity and novel processes and intermediates for their preparation.

REFERENCES:
patent: 3823138 (1974-07-01), Van Rheenen
patent: 4109009 (1978-08-01), Buendia et al.
Chem. Abstracts vol. 87, 3745CS.

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