.beta.-Lactones of 2-hydroxy-cyclopentane-carboxylic acids

Details .beta.-Lactones of 2-hydroxy-cyclopentane-carboxylic acids .beta.-Lactones of 2-hydroxy-cyclopentane-carboxylic acids

1979-11-16

1981-04-28

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

26034321, 542426, 542429, 542430, 542431, 560122, 562504, C09B 2316, C09B 2308, C07D30514, A61K 31365

Patent

active

042646235

ABSTRACT:
Novel .beta.-lactones of 2-hydroxy-cyclopentane-carboxylic acids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl and R.sub.2 is selected from the group consisting of --CH.sub.2 --O--CH.sub.2 --CH.sub.3 and --X--Ar, X is selected from the group consisting of --O-- and --CH.sub.2 --, Ar is an optionally substituted member selected from the group consisting of thienyl, thiazolyl, phenyl and thiadiazolyl, the optional substituents being at least one member selected from the group consisting of halogen and --CF.sub.3 and thw wavy lines indicate that the groups may be in the .alpha., .beta. or .beta., .alpha.-positions or mixtures thereof having hypotensive activity and their preparation.

REFERENCES:
patent: 4024179 (1977-05-01), Bindra et al.
patent: 4113766 (1978-09-01), Hess

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