.beta.-lactams useful in determining the amount of elastase in a

Details .beta.-lactams useful in determining the amount of elastase in a .beta.-lactams useful in determining the amount of elastase in a

1992-01-03

1993-07-20

Berch, M. L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07D40512, C07D41312, A61K 31395

Patent

active

052295109

ABSTRACT:
Disclosed are .beta.-lactams of formula I ##STR1## wherein X is a chromogenic or fluorogenic substituted aryl or heteroaryl, which are specific inhibitors of Human leukocyte elastase (HLE). Upon contact with HLE these compounds are cleaved to form a chromogenic or fluorogenic species which may be readily measured by the assay disclosed herein. The assay thus provides a means for direct measurement of the amount of active HLE in a body fluid or other sample.

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Tanaka, et al Heterocycles vol. 24, No. 9, pp. 2539-2543 (1986).

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