.beta.-Lactams, their production, intermediates thereto and deri

Details .beta.-Lactams, their production, intermediates thereto and deri .beta.-Lactams, their production, intermediates thereto and deri

1976-10-28

1979-12-11

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393R, 26032645, 26032613B, 2603407, 2603409R, 546243, 549 49, C07D20508, C07D40506

Patent

active

041782860

ABSTRACT:
.gamma.-lactones are converted into both known and new azetidine carboxylic acids which can be transformed readily to the corresponding .beta.-lactams by oxidative decarboxylation. The .beta.-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams such as nocardicin.

REFERENCES:
Trost et al., J. Amer. Chem. Soc. 97, 3528-3530 (1975).
Yanulla et al., Tet. Letters 1968, 1725-1787.

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