Beta-lactams, their production from azetidine carboxylic acids,

Details Beta-lactams, their production from azetidine carboxylic acids, Beta-lactams, their production from azetidine carboxylic acids,

1977-09-08

1979-08-07

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032613B, 26032615, 260338, 2603407, 2603409R, 2603303, C07D20508, C07D40706, C07D40306, C07D40506

Patent

active

041637437

ABSTRACT:
Azetidine-2-carboxylic acids are transformed readily to the corresponding beta-lactams by iminium salt formation and reaction of the salt with a suitable nucleophile. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams such as nocardicin.

REFERENCES:
R. T. Dean et al., J. Amer. Chem. Soc. 98, 7448-49 (1976).
Blaha et al., J. Het. Chem. 6, 216 (1966).

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