Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-02-19
1986-10-14
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540300, 544 69, 544 71, 544 90, C07D49804, C07F 710
Patent
active
046171525
ABSTRACT:
A process is described for selectively obtaining 1-.beta.-methylcarbapenem intermediates. The desired chirality is obtained through the hydrogenation of certain bicyclic .beta.-lactam ring structures containing an exocyclic methylene double bond alpha to the .beta.-lactam ring, in the presence of a Group VIII metal hydrogenation catalyst. The hydrogenation results in a mixture of .alpha.- and .beta.-methyl epimers having a high .beta./.alpha. epimeric ratio. New 1-.beta.-methylcarbapenem intermediates made by the process are also described.
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Heterocycles, 1984, vol. 21, pp. 29-40, by D. H. Shih, et al.
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Cama Lovji D.
Christensen Burton G.
Schmitt Susan M.
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
Raymond Richard L.
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