Beta-lactams and their production via stereospecific hydrogenati

Details Beta-lactams and their production via stereospecific hydrogenati Beta-lactams and their production via stereospecific hydrogenati

1990-06-12

1991-12-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540300, C07D20508, C07D49804, C07B 5300

Patent

active

050754351

ABSTRACT:
A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group or a 1-hydroxy(lower)alkyl group wherein the hydroxyl group is optionally protected, R.sub.2 is a hydrogen atom or a protective group for the nitrogen atom and R.sub.3 is a methyl group, a halomethyl group, a hydroxymethyl group, a protected hydroxymethyl group, a formyl group, a carboxyl group, a lower alkoxycarbonyl group or an ar(lower)alkoxycarbonyl group wherein the aryl group is optionally substituted, or R.sub.2 and R.sub.3 are combined together to form an oxaalkylene group and, when taken together with one nitrogen atom and two carbon atoms adjacent thereto, they represent a six-membered cyclic aminoacetal group, which is useful as a valuable intermediate in the stereospecific production of 1-methylcarbapenem compounds.

REFERENCES:
patent: 4595750 (1986-06-01), Christensen
Brown, J. Chem. Soc., Chem. Comm. 1982, p. 348.
Evans, J. Amer. Chem. Soc. 106, 3866 (1984).
House, "Modern Synthetic Reactions" pp. 18-23.
"Reagents for Organic Synthesis", vol. 9, (1981), pp. 200, 259, 406.
House, "Modern Synthetic Reactions" pp. 20-31.
Hashimoto, Chem. Abs. 88, 51091e.
Triangalo, Chem. Abs. 83, 10660t.
Toth, Chem. Abs. 89, 179408b.

Affiliated with

Also associated with

Rating

Beta-lactams and their production via stereospecific hydrogenati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Beta-lactams and their production via stereospecific hydrogenati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Beta-lactams and their production via stereospecific hydrogenati will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-44507