Beta-lactamase substrates having phenolic ethers

Details Beta-lactamase substrates having phenolic ethers Beta-lactamase substrates having phenolic ethers

2008-07-08

2008-07-08

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C540S215000, C540S222000, C540S227000, C540S226000, C540S301000, C435S007400, C435S173200

Reexamination Certificate

active

07396926

ABSTRACT:
Provided are fluorescent substrates for β-lactamases having the general formula I:in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R′ is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, —CHR2OCO(CH2)nCH3, —CHR2OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, β-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R2is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2and CH2; and Z is a donor fluorescent moiety. Also provided are methods of use of the compound of general formula I.

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