.beta.-lactamase inhibitory composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514210, 514435, A61K 31545, A61K 31395, A61K 31535

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active

047255919

ABSTRACT:
Compounds having one or two substituents at the 3-position, represented by the general formula ##STR1## wherein R.sub.1 is an optionally acylated or protected amino group and X is hydrogen atom or methoxy group, or a pharmaceutically acceptable salt thereof; when used either alone or in combination with a .beta.-lactam antibiotic, show excellent .beta.-lactamase inhibitory activity and can be used as drugs for use in humans and domestic animals.

REFERENCES:
patent: 4225586 (1980-09-01), Imada et al.
patent: 4229436 (1980-10-01), Imada et al.
Shibuya et al., Heterocycles, vol. 12, No. 10, 1979, pp. 1315-1318.
Sykes et al., Nature, vol. 291, pp. 489-491 (1981).
Aoki et al., The Japanese Journal of Antibiotics, vol. XXX Supl., pp. S-207-S-217 (1977).
Reading et al., Antimicrobial Agents and Chemotherapy, vol. 11, No. 5, May 1977, pp. 852-857.
Matsuo et al., Chem. Abs. 97, 162701j (1982).

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