Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1978-05-18
1980-05-27
Shapiro, Lionel M.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
435170, 435184, 435868, 435867, A61K 3764
Patent
active
042050685
ABSTRACT:
A substance which inhibits the enzyme .beta.-lactamase, produced by a wide range of microorganisms, is obtained when species of the microorganism Micromonospora are cultivated under aerobic fermentation conditions and this inhibitor can be isolated from the fermentation medium by extraction. This substance, denominated EM4615, is useful to enhance the effectiveness of .beta.-lactam antibiotics such as penicillins and cephalosporins.
REFERENCES:
patent: 4078056 (1978-03-01), Weinstein et al.
Journal of Antibiotics, (Japan), vol. 27, pp. 493-501, (1974).
Journal of Antibiotics, (Japan), vol. 25, pp. 473-474, (1972).
Journal of Antibiotics, (Japan), vol. 26, pp. 51-54, (1973).
Liu Wen C.
Principe Pacifico A.
Sykes Richard B.
Wells J. Scott
Barrack Donald J.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Shapiro Lionel M.
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