Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl-(5R)

Details Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl-(5R) Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl-(5R)

1981-09-14

1982-10-26

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

2602391, 2602452R, 424270, 424271, A61K 3143, A61K 31425, C07D49968, C07D51304

Patent

active

043561748

ABSTRACT:
Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxides and esters thereof, wherein the 2-beta-substituent is cyano, acetyl, alkoxycarbonyl, omegahydroxyalkoxycarbonyl, carbalkoxymethoxycarbonyl or dialkylaminocarbonyl; intermediates therefor wherein the 2-beta-substituent is carboxy, chlorocarbonyl or aminocarbonyl; methods for their preparation and use as beta-lactamase inhibitors.

REFERENCES:
patent: 4234579 (1980-11-01), Barth
patent: 4241050 (1980-12-01), Barth
patent: 4244951 (1981-01-01), Bigham
patent: 4256733 (1981-03-01), Barth
patent: 4287181 (1981-09-01), Kellogg
Cooper, J. Am. Chem. Soc. 94, 1018 (1972).

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