Beta-lactamase diagnostic product and method

Details Beta-lactamase diagnostic product and method Beta-lactamase diagnostic product and method

1978-11-24

1980-11-18

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 24, 435 29, 435 32, 435 34, 252408, C12Q 134, C12Q 136, C12Q 104

Patent

active

042346835

ABSTRACT:
A diagnostic product and method are provided for rapid, sensitive and reproducible screening of penicillin resistance in bacteriological species such as Neisseria gonorrhoeae and Haemophilus influenzae. The diagnostic product and method of the present invention are utilized with aqueous solutions of iodine. The product includes four components; a porous support; a starch; a substrate such as penicillin and, a nucleophilic reagent. Preferred embodiments include a particular nucleophilic reagent which provides assay results in about 10 to about 30 seconds. The best mode contemplated for the diagnostic product is an embodiment in the form of a kit.

REFERENCES:
patent: 2601350 (1952-06-01), Welch
patent: 3616251 (1971-10-01), Linoti
patent: 3830700 (1974-08-01), O'Callaghan et al.
patent: 4066509 (1978-01-01), Ceska
R. P. Novick, Biochemistry Journal, vol. 83, pp. 236-240, 1962.
C. Thornsberry et al., Antimicrobial Agents and Chemotherapy, vol. 6, No. 5, pp. 653-654, 1974.
James H. Jorgensen et al., Antimicrobial Agents and Chemotherapy, vol. 11, No. 2, pp. 1087-1088, 1977.
Tolu Odugbemi et al., British Medical Journal, p. 500, 1977.
B. Wesley Catlin, Antimicrobial Agents and Chemotherapy, vol. 7, No. 3, pp. 265-270, 1975.

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