Beta-lactam derivatives of the 4-acylcephem sulphone and 3-acylp

Details Beta-lactam derivatives of the 4-acylcephem sulphone and 3-acylp Beta-lactam derivatives of the 4-acylcephem sulphone and 3-acylp

1989-04-10

1991-12-31

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514202, 514203, 514204, 540221, 540222, 540225, 540227, 540230, C07D50120, A61K 31545

Patent

active

050772864

ABSTRACT:
Compounds of formulae Ia and Ib ##STR1## wherein A is hydrogen atom or an organic residue, R.sup.1 is halogen atom, or an organic group, R.sup.2 is hydrogen or halogen atom, C.sub.1 -C.sub.4 alkyl or alkoxy group, R.sup.3 is hydrogen atom, C.sub.1 -C.sub.4 alkyl or alkoxy group, benzyl or a methylene group and R.sub.4 is an organic residue are disclosed. Compounds (Ia) and (Ib) are endowed with elastase inhibitory activity. A two-step process for their preparation starting from the corresponding 4-carboxy cephem or 3-carboxy penam is also provided.

REFERENCES:
patent: 4547371 (1985-10-01), Doherty et al.
patent: 4637999 (1987-01-01), Doherty et al.
"Enclosure 1" (10 pages) Reference: HLE Role, etc.

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