.beta.-Lactam compounds, antibacterial compositions thereof and

Details .beta.-Lactam compounds, antibacterial compositions thereof and .beta.-Lactam compounds, antibacterial compositions thereof and

1980-12-04

1982-08-03

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602391, 2602452R, 2602453, A61K 3143, C07D49968, C07D49970

Patent

active

043427723

ABSTRACT:
The present invention relates to hitherto unknown compounds of the general formula I: ##STR1## in which R.sub.1 stands for a phenyl, 4-hydroxyphenyl, 1,4-cyclohexadienyl or a 3-thienyl group; R.sub.2 represents a primary amino or a carboxy group; R.sub.3 is a hydrogen atom, or a lower alkyl, aryl or aralkyl radical, and A stands for a radical of a .beta.-lactamase inhibitor containing a .beta.-lactam ring as well as a carboxy group, A being connected via the carboxy group.
The present invention provides new compounds useful in the treatment of bacterial infections. The new compounds are in particular strongly active against .beta.-lactamase producing bacteria.

REFERENCES:
patent: 3838152 (1974-09-01), Hou et al.
patent: 3869449 (1975-03-01), Godtfredsen
patent: 3981865 (1976-09-01), Saikawa et al.
patent: 4181659 (1980-01-01), Hansen
patent: 4197240 (1980-04-01), Nudelman et al.
patent: 4244951 (1981-01-01), Bigham

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