.beta.-lactam compounds and production process thereof

Details .beta.-lactam compounds and production process thereof .beta.-lactam compounds and production process thereof

1991-08-12

1993-03-02

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07B 5500, C07B 3704, C07D20508, C07F 710

Patent

active

051910748

ABSTRACT:
A process for producing a .beta.-lactam compound of the formula ##STR1## wherein OR.sup.1 is a protected or unprotected hydroxyl group; R.sup.2 is a C.sub.1 to C.sub.7 alkyl or aryl group; from an azetidinone compound of the formula ##STR2## wherein X is an electronegative group removable through the reaction in three steps in which the second step subjects the .beta.-lactam compound obtained in the first step to silylation to convert the R.sup.2 group to the beta form.

REFERENCES:
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patent: 4709064 (1987-11-01), Shibasaki, II
patent: 4816577 (1989-03-01), Bender
Shibaski I Tet. Letters 23, 2875 (1982).
Yamaguchi, Chem Letters 1987, 1519-22.
Keinan, J. Org. Chem. 48, 5302-09 (1983).
Prasad, Tet. Letters 29, 4257-60 (1988).
"8th Symposium on Medicinal Chemistry" (Osaka, 1986) pp. 21-24.
Chapman, "Correlation Analysis in Chemistry-Recent Advances" pp. 461. 463.
Shih, Heterocycle 21, 29-40 (1984).

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