Drug – bio-affecting and body treating compositions – Plural fermentates of different origin
Patent
1995-06-09
1996-02-27
Rizzo, Nicholas
Drug, bio-affecting and body treating compositions
Plural fermentates of different origin
540205, 540214, 514210, 5142245, C07D51304, A61K 3154
Patent
active
054946662
ABSTRACT:
Compounds of the formula ##STR1## where Z, A, and R are as disclosed herein and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds are disclosed.
The compounds have .beta.-lactamase inhibiting properties and are useful in the control of .beta.-lactamase-forming pathogens in combination with .beta.-lactam antibiotics. They also exhibit antibacterial activity of their own and can accordingly be used themselves in the control or treatment of infectious diseases.
REFERENCES:
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patent: 4018782 (1977-04-01), Wolfe
patent: 4140688 (1979-02-01), Perchonck
patent: 4220766 (1980-09-01), Tsuji et al.
patent: 4525304 (1985-06-01), Hull et al.
patent: 4956358 (1990-09-01), Morimoto et al.
patent: 5055463 (1991-10-01), Greenlee et al.
Derwent Abstract No. AN 92-341562/42. (1992).
Chemical Abstracts, vol. 119:11702s (1993).
Bohringer Markus
Hubschwerlen Christian
Pflieger Philippe
Specklin Jean-Luc
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Kass Alan P.
Rizzo Nicholas
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