Drug – bio-affecting and body treating compositions – Plural fermentates of different origin
Patent
1995-03-03
1995-11-07
Rizzo, Nicholas
Drug, bio-affecting and body treating compositions
Plural fermentates of different origin
514210, 540205, C07D48704, A61K 31395
Patent
active
054646170
ABSTRACT:
Compounds of the formula ##STR1## where Z, A, and R are as disclosed herein and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds are disclosed.
The compounds have .beta.-lactamase inhibiting properties and are useful in the control of .beta.-lactamase-forming pathogens in combination with .beta.-lactam antibiotics. They also exhibit antibacterial activity of their own and can accordingly be used themselves in the control or treatment of infectious diseases.
REFERENCES:
patent: 3950352 (1976-04-01), Wolfe
patent: 4140688 (1979-02-01), Perchonckl
Chemical Abstracts vol. 119: 11702s (1993).
Derwent Abstract No. AN 92-341562/42 (1992).
Bohringer Markus
Hubschwerlen Christian
Pflieger Philippe
Specklin Jean-Luc
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Kass Alan P.
Rizzo Nicholas
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