.beta.-Lactam antibiotics, their preparation and their use in ph

Details .beta.-Lactam antibiotics, their preparation and their use in ph .beta.-Lactam antibiotics, their preparation and their use in ph

1980-10-28

1983-06-07

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424114, 42424851, 424246, 424260, 424269, 424270, 424272, 424274, 544 61, 544144, 546272, C07D48704

Patent

active

043870511

ABSTRACT:
The present invention provides the compounds of the formula (II): ##STR1## and pharmaceutically acceptable salts and esters thereof wherein R.sup.3 is a hydrogen atom, a group HO.sub.3 S-- or a group R.sup.5 CO wherein R.sup.5 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, aryl, aryl(C.sub.1-6)alkyl or aryloxy(C.sub.1-6)alkyl; and R.sup.4 is an organic group other than methyl bonded to the --CO--NH-- moiety via a carbon atom; with the proviso that when R.sup.3 is a hydrogen atom or a group R.sup.5 CO the stereochemical configuration at the .alpha.-carbon atom of the C-6 substituent is S, and with the further proviso that when R.sup.3 is a group HO.sub.3 S-- the hydrogen atoms at C-5 and C-6 are cis. Their use is described as are processes for their preparation. Compounds wherein the R.sup.4 CO-- moiety is replaced by a hydrogen atom are also prepared.

REFERENCES:
patent: 3926955 (1975-12-01), Burton et al.
patent: 4229443 (1980-10-01), Binderup
patent: 4231928 (1980-11-01), Naito et al.
patent: 4232030 (1980-11-01), Christensen et al.
patent: 4237051 (1980-12-01), McCombie
patent: 4244965 (1981-01-01), Howarth et al.
patent: 4246262 (1981-01-01), Vangedal
patent: 4252722 (1981-02-01), Melilo et al.
patent: 4278686 (1981-07-01), Corbett et al.

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